Oestrogen and progestogen receptor content in human endometrium
نویسندگان
چکیده
منابع مشابه
Oestrogen and progestogen receptor content in human endometrium.
The cyclic process of proliferation, secretory differentiation, (pre)decidualization, menstrual degeneration and regeneration in premenopausal endometrium is controlled by oestrogens and progestogens, and is mediated through binding to their specific receptors. Oestrogen (ER) and progestogen receptor (PR) presence and concentration indicate not only hormonal influence on the specific cells but ...
متن کاملSynthetic progestogen-oestrogen therapy and uterine changes.
Continuous therapy with synthetic progestogen-oestrogen produces marked atrophy of endometrial glands and massive pseudodecidual stromal transformation. Cyclical therapy produces initially a ;frustrated secretory response' with precocious attempts at secretion in poorly developed glands. Pseudodecidua appears about the 20th day. With later cycles there is progressively greater gland atrophy whi...
متن کاملOestrogen receptor α and β mRNA expression in human endometrium throughout the menstrual cycle
We examined the localization of oestrogen receptor (ER) β mRNA in the human endometrium throughout the menstrual cycle using non-radioactive in-situ hybridization with Brigati-tailed oligonucleotides. The findings were compared with those of ERα in order to examine the possible biological significance of ERβ in the human endometrium. Both ERα and ERβ mRNA expression were detected in all major h...
متن کامل[Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy. A follow up study].
OBJECTIVE To determine effects of five years of treatment with an oral continuous combined regimen of 2 mg 17beta-oestradiol and 1 mg norethisterone acetate on endometrial histology in postmenopausal women. DESIGN Follow up study in postmenopausal women. SETTING 31 menopause clinics in the United Kingdom. PARTICIPANTS 534 postmenopausal women, all with an intact uterus, who had completed ...
متن کاملOestrogen receptor in glands and stroma of normal and neoplastic human endometrium: a combined biochemical, immunohistochemical, and morphometric study.
Cryostat sections of unfixed human endometrial tissue from normal, hyperplastic, and carcinomatous endometrium were assayed for oestrogen receptor content using a radiolabelled oestradiol binding assay with isoelectric focusing to separate receptor proteins. The proportions of myometrium, stroma, and glandular tissue were estimated in adjacent sections by point counting. Further cryostat sectio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Obstetrics & Gynecology and Reproductive Biology
سال: 1996
ISSN: 0301-2115
DOI: 10.1016/s0301-2115(96)02566-3